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Dihexa offers a mechanistically intriguing but unvalidated probe for HGF/c-Met neurobiology, with the critical caveat that its core published evidence is under question

Jurez E, Ruiz A, Cortez O, Sada E, Torres M

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While early research and anecdotal evidence are promising, these peptides are still being studied and are not FDA-approved for medical use

10.1097/BOR.0b013e3282f4b1ed 123 RagabG.ElshahalyM.BardinT

Research frequently cites 0.5% as an effective sweet spot, balancing meaningful results against low irritation risk