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The CDC considers a person to have died from Alzheimer's if the death certificate lists Alzheimer's as the underlying cause of death, defined as the disease or injury which initiated the train of events leading directly to death. 468 Severe dementia frequently causes complications such as immobility, swallowing disorders and malnutrition that significantly increase the risk of acute conditions that can cause death

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EP300 usually regulates transcription factors mainly through acetylation and further activates cell cycle-related genes, thus affecting the progression of cancers 39

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