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We're always talking about histamine, and yes, histamine does play a large role in a lot of the symptomology we see, but mast cells have lots of other mediators, most of which are pro-inflammatory the tryptases, the proteases, the prostaglandins, the bradykinins, leukotrienes, and so on
Nature , 1980 Practically, this is why GHK-Cu outperforms free GHK or plain copper salts: it's the chaperoned delivery that drives the downstream signaling
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