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The cultured SGN explants from WT or gpx1 / mice were exposed to peroxynitrite with or without ebselen pretreatment, and the expression changes of 4-HNE were examined to evaluate the oxidative stress level in SGNs (Figure 5A)

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While some discrepancies remain, most notably opposing findings on the size of IPSC reduction after Aldh1a1 knockout (Kim et al., 2015

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A whole cottage industry is springing up to test these research compounds