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This decline is now recognised across multiple landmark studies as a primary driver of mitochondrial dysfunction, impaired DNA repair, sirtuin silencing, and the systemic metabolic deterioration that defines biological ageing

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Gu Y, Li X, Chen H, Sun Y, Yang L, Ma Y, Yong Chan ECY (2022) Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

Both groups experienced a decrease in body weight and BMI, though without significant inter-group differences

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