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Overexpression of parkin protects retinal ganglion cells in experimental glaucoma
Upregulation of the mitochondrial calcium uniporter (MCU) contributes to calpain/OPA-1-mediated inhibition of mitophagy, suppressing excessive apoptosis through OPA1 [99]
A phase II clinical trial that investigated the efficacy of VK2809 found that participants who received VK2809 exhibited notable reductions in their liver fat contents as determined by the magnetic resonance imaging proton density fat fraction (MRI-PDFF) technique compared with those who received a placebo
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they also accelerate the breakdown of existing collagen through the activation of enzymes called matrix metalloproteinases (MMPs)
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