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In this pathway, NOS catalyzes the conversion of L-arginine and oxygen to L-citrulline and NO ( NOS-dependent NO production is facilitated by three tissue-specific NOS isozymes, namely, nNOS, eNOS, and iNOS ( Stimulation of NO production via the NOS-dependent pathway nNOS and eNOS are calciumcalmodulin-dependent enzymes responsible for the conversion of L-arginine and oxygen to L-citrulline and NO ( Exercise as a stimulant for NO production via the NOS-dependent pathway Exercise is a stressor that is known to stimulate NOS-dependent NO production