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Injection is often the most immediate and potent option, while oral supplements provide a gradual improvement over time

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doi: 10.1080/25785826.2021.1930371 199 AttiasMAl-AubodahTPiccirilloCA

In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)

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