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They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

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After three days of the treatment protocol, also the serum levels of TNF- , IL-6, and ICAM-1, as proinflammatory cytokines, decreased more in the ALC group than in the placebo group ( p value = 0.04, 0.02, and 0.03, respectively)

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Cell Cycle 11 , 41074108 (2012)