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A large study of 2,000 obese adults found that participants using semaglutide combined with diet and exercise lost up to 15-20% of their body weight after 68 weeks

Its frequently chosen when the goal isnt just weight loss, but improving how the body uses fuelsupporting energy production and metabolic efficiency

In some patients, they may also signal nutritional deficiency, worsening of an underlying condition, or the need for medical intervention

2021;137(6):e128-e144

Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects

2012;7(1):e29794