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Animal models or patient-derived xenografts could provide a more comprehensive understanding of how chemotherapeutic hormesis occurs within the complex TME

Hypoglycemia is a known risk with IGF-1 analogs due to their insulin-like metabolic effects, and IGF-1 DES's high potency increases this risk

While non-activated microglia preferentially use oxidative phosphorylation, activated microglia undergo a metabolic reprogramming, with increased glucose uptake and strengthening of anaerobic glycolysis, to increase ATP production [65]

(153) found that TRF had anti-convulsive effects by prolonging the latency to forelimb clonic seizures, reducing the seizure severity score, and reducing the number of animals reaching status epilepticus

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