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Heart failure therapy by GLP-1RAs Although a meta-analysis of large-scale clinical trials suggested that GLP-1RAs reduce heart failure hospitalizations (HHF) by approximately 10% in patients with diabetes at high cardiovascular risk [22, 23], the treatment effects on the risk of HHF in individual trials other than AMPLITUDE-O were not significant (Tables 1, 2)

They were getting spondys, they were getting facet syndrome, SI joint syndrome, and they didnt say it specifically, but they referenced a lot of sciatica-type issues, which you would say is kind of more discogenic or herniation-related

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Thats why we thought it best to explore semaglutide and B12 levels, including their relationship with one another and medication management strategies