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In HNSCC, HGF is majorly secreted via tumor-associated fibroblasts (TAFs) in the tumor microenvironment [80, 81]

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Using the large 3.0 mL dilution keeps the working dose at 1260 units for reliable measuring accuracy

Biological Chemistry 295, 96769690

Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system