Reduced toxicity, myeloablative conditioning with BU, fludarabine, alemtuzumab and SCT from sibling donors in children with sickle cell disease
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Concurrently, p53 dysfunctionvia mutation or epigenetic silencingcompromises DNA damage response, enabling survival of genomically unstable clones (Macedo-Silva et al., 2023)
Key points Neoangiogenesis and synovial expansion induce a bioenergetic crisis in the inflamed joint in rheumatoid arthritis (RA)
If these early signs hold up in humans, peptides could soon be part of new fertility treatments
The patient had a history of migraines, anxiety, colon polyps, and gastroesophageal reflux disease