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Table 3: Treatment dates and TruAge measurements

GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others

Many compounds have looked like magic in animals only to disappoint in human trials or reveal hidden risks later

Animals and Treatment Male (APP/PS1) mice and wild-type (C57) mice were purchased from Beijing Zhishan Company (Beijing, China)

As the selenium concentration increased, both yeast strains showed an increased GSSG content

These gene sets were not enriched in GPX4 perturbed cells in the absence of giredestrant, consistent with the screen results that identified GPX4 as a giredestrant-dependent vulnerability (Supplementary Fig