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Clinical studies show that while GLP-1 peptides like semaglutide and tirzepatide primarily reduce fat mass, some lean muscle is lost as well

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External resources PubMed: AOD 9604 lipolytic activity study - Research on AOD 9604 mechanism of action in adipose tissue New England Journal of Medicine: STEP 1 Trial - Landmark semaglutide weight loss trial with 1,961 participants FDA: Semaglutide safety information - Official FDA information on approved semaglutide formulations WADA Prohibited List - Current prohibited substances list including growth hormone fragments ClinicalTrials.gov: Semaglutide trials - Registry of ongoing and completed semaglutide clinical trials Choosing between AOD 9604 and semaglutide is ultimately a decision that depends on your individual circumstances, health status, and weight loss goals

For people with more subcutaneous fat, the layer may be 15-20mm or deeper, making it nearly impossible to accidentally inject into muscle even at a 90-degree angle

This interaction helps explain both its vascular effects and its apparent benefits for various organ systems beyond musculoskeletal tissues

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