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Thiamine works as a co-enzyme for complexes including enzymes essential for intracellular glucose metabolism, such as transketolase, pyruvate dehydrogenase (PDH), and -ketoglutarate dehydrogenase

Patients should always consult qualified healthcare professionals regarding peptide therapy options, treatment plans, and safety considerations

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The evidence base here is thin and largely theoretical, but the concept aligns with established pharmacology of intranasal peptide delivery systems used for other compounds

Specifically, in recent years, much attention has been paid to the identification and selection of natural bioactive molecules, especially polyphenols, which are effective in the prevention and treatment of UTIs

Acknowledgements The authors are very grateful to Stephen M