McIntosh CH, Widenmaier S, Kim S-J
Rahman I, Mulier B, Gilmour PS, Watchorn T, Donadlson K, Jeffery PK, MacNee W: Oxidant-mediated lung epithelial cell tolerance: The role of intracellular glutathione and nuclear factor-B
Key Regulatory Points: Not FDA-approved for any medical indication Cannot legally be sold as a drug, food, or dietary supplement for human consumption Legally sold as a "research chemical" not intended for human use Compounding pharmacy restrictions were significantly tightened in late 2024 Sports / WADA CJC-1295 is explicitly prohibited by the World Anti-Doping Agency (WADA)
FDA safety concerns The FDA includes DSIP on its list of bulk drug substances with potential safety risks
Thus, TB-500 may be hypothesized to support angiogenesis by combining a cytoskeleton-linked increase in endothelial motility with signaling changes that raise pro-angiogenic programs (VEGF-A and Ang2/Tie2) via Notch/NF-B coupling in damaged cellular structure
In view of the high expression of this transporter in colon, it has been proposed to participate in absorption of the microbiota-generated ThDP (25)
