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While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

Moreover, their results also supported the notion that AGE production may be prevented or even diminished by antioxidant supplementation with vitamin B derivatives [305, 306], and/or vitamins A, C, and E [307]

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PagliariniDJCalvoSEChangBShethSAVafaiSBOngSEet al

Grunea, and A

Research utilizing single-cell Raman microspectroscopy has demonstrated that ME/CFS patients exhibit significant aberrations in ROS clearance pathways, including elevated oxidative stress markers and reduced antioxidant enzyme activity