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Oral bioavailability would then be higher than predicted, based on consideration of hepatic extraction ratio and f H

Neither compound has published the kind of long-term hard-outcome data (cardiovascular events, mortality) that ultimately defines a metabolic drugs value, because both are too early in development for that

The compound's mechanism of action involves interaction with specific receptors, which can lead to both intended effects and unintended consequences that researchers classify as side effects

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