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Clinical trials have also reported that onion (quercetin-rich source) intake for 24 weeks reduced cognitive decline, possibly by reducing depressive symptoms and improving emotional state, compared to placebo food group, in Japanese individuals of age-group 6079 years [97]

From a gut microbiota perspective, Gryp et al

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Copper plays an important role in enzyme activity, connective tissue formation, antioxidant defense, and cellular energy production but copper doesnt always move efficiently through the body on its own

Some concerns were reported in one study regarding bias due to deviations from the intended intervention

( ( Based on the results of these analyses, we are proposing to change the scoring methodology to award HEA bonus points (with a measure performance scaler of 0, 2, and 4 points) because this option allows more hospitals treating a large share of patients with DES to gain from the HEA bonus, particularly safety net hospitals