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Glutathione-mediated detoxification systems in plants

Unfolded protein accumulation also induces NLRP3 inflammasome activity [54]

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Recent research shows that OTA causes cell cycle arrest in the G1 and G1/S phase, which is mediated by p53 and suppressed in HK-2 by cyclin D1, Cdk2, and Cdk4 (70)

In RCC, PROTAC PpD promotes the ubiquitinated degradation of P21-activated kinase-4 (PAK4), which in turn inhibits tumor proliferation and increases tumor cell death by immune cells[85]