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Furthermore, we found that the expression of the p-NF-B p65 protein was upregulated in peroxynitrite-exposed SGNs compared with the untreated controls, and the pretreatment with ebselen significantly reduced it while the lack of GPX1 increased it (Figure 8C)

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[ 111 , 112 , 113 , 114 ] HIF1 induction induced by hypoxia or dimethyloxaloylglycine (DMOG) increases BACH1 expression and attenuates NRF2dependent HO1 induction in human endothelial cells