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A treatment course of 4-8 weeks is typically recommended for best results, with ongoing assessments to evaluate effectiveness and decide whether to continue

The SURMOUNT-4 trial specifically studied what happens when tirzepatide is stopped after 36 weeks of treatment

In specific embodiments, any formulation or composition described herein has a pH that allows for terminal sterilization (e.g., by heat treatment and/or autoclaving) of a formulation or composition without degradation of the therapeutic agent

However, formulators should avoid high concentrations of chelating agents such as EDTA, as they may interfere with copper binding

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