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Notably, we previously showed that administering Tempol (a potent ROS scavenger) or genetically deleting Ncf1 (which impairs the respiratory burst) led to bacterial outgrowth in mice 7

The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid