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Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms

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Proteolysis and carbohydrate transport, as well as microautophagy of the nucleus were downregulated at 3 hpi and 24 hpi, whereas also GPI-anchor biosynthesis, DNA break repair, and aromatic amino acid catabolism were downregulated at 24 hpi (Fig

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