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Dysbiosis increases gut permeability, allowing endotoxins to enter the bloodstream

Eur J Med Chem 185:111777

And Im not sure if you would tie in immune system and tissue injury and tissue repair together

88 Notably, antagonism of GH signaling has the added benefit of suppressing the IGF1-mediated effects, which contribute to the etiology of several disease indications in a manner similar to that described above