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It is well established that humans can smoke for years without any major health complications, while rodents can be exposed for months on end without any ill effect

Additionally, the RPE physically interacts with the outer retinal blood supply, known as the choroid, forming a structure known as the outer bloodretinal barrier (BRB)

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doi: 10.3389/fphar.2025.1567863 Received 28 January 2025 Accepted 21 April 2025 Published 01 May 2025 Volume 16 - 2025 Edited by Miguel Oliveira, University of Aveiro, Portugal Reviewed by Yuling Han, Chinese Academy of Sciences (CAS), China Gary Ten Eyck, New York University, United States Satish Polshettiwar, MIT World Peace University, India Updates Copyright 2025 Feng, Qu and Hao

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