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Then, tissue samples were cut and weighed into 100 mg sections and mixed with 400 L of methanol in tubes containing 1.0-mm zirconia beads (BioSpec Products, USA) and homogenized using a BeadBug bead homogenizer (Benchmark Scientific, USA) at 4000 rpm for 2 min

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This leads to a deficiency of the vitamin and consequently, a type of anemia known as megaloblastic anemia

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