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Indeed, biguanides including phenformin showed clinical benefit in diabetic influenza patients and hence the compound was suggested as a COVID treatment option 65

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(20%) , 3

The hydrogen bond interactions and corresponding amino acid residues of the target proteins are summarised in Table 4

This doesn't mean they don't happen, of course, as identifying single point sources of infection is notoriously difficult

Tiopronin is also a registered medication for preventing kidney stones in patients with cystinuria and it shares structural similarity with penicillamine due to the presence of a sulfhydryl group [58]