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140,141,142 Traditionally, lactate was considered to be a minor byproduct of glucose utilization in anaerobic environments, but studies now indicate that lactate is an irreplaceable and primary fuel for energy and is crucial for the TCA cycle

Kaur R, Sood A, Lang DK, Arora R, Kumar N, Diwan V, et al

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However, even slight variations, such as alterations in the dimensions of lipoprotein particles and an elevation in LDL II and IV subtypes, could potentially contribute to an increased susceptibility to macrovascular disease in people [107]

The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129

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