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Lysyl oxidase Copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin, producing aldehydes that participate in cross-linking reactions essential for mature extracellular matrix mechanical properties
Conversely, hepatocyte-specific Cdo1 overexpression independently lowered hepatic lipids and improved liver function, and exerted a synergistic effect with exercise
COPD J Chronic Obstr Pulm Dis 7:285290
For IHC staining, primary antibodies (GPX4 (ab125066), SLC7A11 (ab307601), IL-6 (21,8651-AP), TNF- (26,4051-AP), COX2 (27,3081-AP), and MMP13 (18,1651-AP)) were applied at a dilution of 1:200 and incubated overnight at 4 C, followed by incubation with an HRP-conjugated secondary antibody and DAB color development
Three iron chelators are currently FDA-approved: deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP)
