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Furthermore, we found that inhibitors of the MAPK pathway (PD98059) and the PI3K/ATK pathway (LY294002) effectively neutralized the promotion effect of miR-221 antagomir on proliferation and G1 to S cell cycle transition in DPCs and DSCs, respectively, as demonstrated by CCK-8, EdU, and cell cycle assays (Fig

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With the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, it exhibits stability against enzymatic degradation and gastric acidity

It targets pigmentation through multiple pathways without being too harsh