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Manipulation of genes encoding enzymes for, e.g., folate biosynthetic and salvage pathway, polyglutamylation, and folate binding proteins, has been carried out with some achievements 2,10,25,34,303,310,560,752,754,776,791,792,793,794,795,796,797,798,799,800,801,802

Vitamin B12 also plays a key role in DNA synthesis, supports cell growth and repair, and contributes to energy metabolism

Journal of Materials Chemistry B

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Yeast has a high content of folate, but also the ability to synthesize the vitamin during fermentation, and this may compensate for folate losses during baking