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The recommended 5-Amino-1MQ dosage for subcutaneous (subQ) injection ranges from 150-500 mcg daily

The use of hydroxocobalamin became first line due to its low adverse risk profile, rapid onset of action, and ease of use in the prehospital setting

This rapid increase has been argued to be due either to a release of IGF-1 stores in tissues or due to a proteolytic cleavage of IGFBP-3 either in the plasma or in tissue

Treatment ranges from basic skincare to medical therapy , including moisturizers, lifestyle changes, and hormone therapy when appropriate

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American Journal of Clinical Nutrition