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TNF then activated two main inflammation-promoting pathways in the endothelial cells that line the million kidney filtering units, called glomeruli, in each kidney as well as the podocytes, cells that wrap around the tiny capillaries of the filtering units
Cytokine expression is typically induced by the activation of Toll-like receptors (TLRs), which initiate downstream signaling cascades involving NF-B and MAPK pathways [357, 358]
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These metabolites are implicated in physiological and pathological processes such as cartilage dissolution, disruption of boundary layers, and the triggering of self-repair mechanisms
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