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Part A 19 (9-10), 11001112

A more accurate assessment of these values was not possible due to low solubility of these compounds at high micromolar concentrations

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These include the formation and permeability of the BBB, angiogenesis, CBF, the clearance of toxic cellular metabolites, vascular remodeling, and tone, all of which are essential for the normal functioning of the CNS [39]

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This is why the 2ml reconstitution works best for the earlier phases of a protocol when doses are lower