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Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast

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When there is an imbalance in the production of free radicals and the body's ability to combat them, oxidative stress arises

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Overall, redox signaling involving mtROS, the PRX3SRX axis, HIF-1, NRF2, and the NOXNADPH system constitutes a regulatory network through which mitochondrial dysfunction is communicated to the ER, nucleus, lysosomes, and peroxisomes, thereby amplifying organellar stress and shaping cell fate in AP (24, 2634)