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Weeks 5 to 8 (dose escalation to 0.6 mg) Nausea becomes more noticeable in some individuals as the dose doubles

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National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis

Jul 22 2020;21(15)doi:10.3390/ijms21155175

This means that hydroxycobalamin stays in the body for longer periods of time and can provide sustained levels of vitamin B12, which may be beneficial for individuals with severe or chronic vitamin B12 deficiency