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These neurotransmitter effects complement the neurotrophic mechanisms for comprehensive cognitive enhancement
doi: 10.3389/fmolb.2025.1724944 Received 14 October 2025 Revised 18 November 2025 Accepted 30 November 2025 Published 18 December 2025 Volume 12 - 2025 Edited by Maria Barile, University of Bari Aldo Moro, Italy Reviewed by Anna Maria Giudetti, University of Salento, Italy Maria Tolomeo, National Research Council (CNR), Italy Updates Copyright 2025 Schrder, Jalilvand, Kahl, Kaiser and Liebau
All of the above-mentioned steps are regulated through the appropriate signaling pathways modulated by the ROS present in the seminal plasma [17,18]
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Cytotoxicity assays conducted on 3T3 fibroblasts, C2C12 myotubes, PC12 neurons, and RAW macrophages, demonstrated that neither Au nanospheres nor Au-PX-PLGA (0.010.5 mg/mL) caused significant toxicity, with cell viability remaining above 95%
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