One crucial component of this hypothetical signaling pathway is phospholipase C (PLC)
The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreichs ataxia [J]
Nanoscale Adv (2021) 3(13):394253
Before the target cells can use the fatty acids for ATP production and oxidation, the fatty acids with chain lengths of 14 or more carbons must be activated and subsequently transported into mitochondrial matrix of the cells in three enzymatic reactions of the carnitine shuttle
Moreover, iron overload could be alleviated by the only known iron exporter, ferroportin (FPN) that promotes iron transport out of cells and inhibits the production of ROS (Geng et al., 2018)
[DOI] [PubMed] [Google Scholar] 130.Shoham A., Hadziahmetovic M., Dunaief J.L., Mydlarski M.B., Schipper H.M