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We are grateful to Qiuyue Li for helping in sample preparation for proteomic analysis

Every number below has been calculated from the base formula: concentration equals peptide mass divided by water volume

Spahr L, Rubbia-Brandt L, Frossard JL, Giostra E, Rougemont AL, Pugin J, et al

Key metrics to track: Time to fall asleep (sleep latency) Number of nighttime awakenings Deep sleep percentage (if using a wearable) Morning alertness and energy Daytime cognitive performance Stress and cortisol management DSIP's effects on the HPA axis and cortisol regulation suggest potential benefits for stress-related sleep problems

DOI: 10.1016/bs.ircmb.2022.08.001 36