In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )
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The peptide has a uniquely high affinity for copper ions, forming a stable chelate with copper(II) that is more exchangeable than the copper bound to albumin, allowing efficient copper delivery to tissues
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Storck et al., 1992) is also known as excitatory amino acid transporter 1 (EAAT1) (Pines et al., 1992) is also known as excitatory amino acid transporter 2 (EAAT2) (Rothstein et al., 1994