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Treatment is typically conducted for 812 weeks , after which a break or reassessment period is recommended to evaluate response and progress

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[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy

Notwithstanding the encouraging results reported above, this study has several limitations

Therefore, we propose that the role of IGF-1 in this process lies more on the maintenance of a normal pace of proliferation rather than in the initiation of cell division (Wang et al., 2006b)