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Franklin, C
He et al identified an amide derivative of NAC, N-acetylcysteine amide (NACA) in murines as a promising precursor of NAC that increases bioavailability to 67% and increases GSH replenishing capacity by 3-4 fold [68]
[DOI] [PubMed] [Google Scholar] [17].Mussbacher M, Salzmann M, Brostjan C, Hoesel B, Schoergenhofer C, Datler H, et al
Importantly, low Se status has been associated with adverse pregnancy outcomes such as miscarriages, neural tube defects, premature birth, low birth weight, preeclampsia, glucose intolerance, gestational diabetes, and even diaphragmatic hernia [7,8,9,10], albeit its precise role in the etiology of these complications has yet to be clarified
In addition to its role as a cellular antioxidant, because it is present in such high amounts, glutathione also functions as a thiol buffer, maintaining the sulfhydryl groups of many cellular proteins in their reduced form
