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This delivery method bypasses the gastrointestinal system altogether, so persons in risk groups for vitamin B12 deficiency with gastrointestinal issues may turn to the shot option for a quick means of ensuring their body has sufficient stores of vitamin B12 to effectively function

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

4 Discussion This systematic review and meta-analysis provide a comparative evaluation of oral, sublingual, and intramuscular (IM) vitamin B12 supplementation in the management of B12 deficiency

Actual medications may vary depending on the prescribing provider, pharmacy, and applicable regulations

35 MetaxasC.MathisD.JegerC.HersbergerK

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