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Understanding the system-specific toxicities is essential for effective management and for tailoring therapy to individual patient needs

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Pickart and Margolina's 2018 review catalogued over 4,000 human genes reportedly modulated by GHK-Cu exposure, including upregulation of collagen synthesis genes (COL1A1, COL4A1), matrix metalloproteinase regulators, and antioxidant enzymes [11]

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