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Addressing these gaps will require integrated multi-omics and subcellular-resolution studies to establish a more precise and context-dependent regulatory framework for ferroptosis

Curr Top Nutraceuticals Res

This increase in ECM proteins fibrosis separates the individual bundles of muscle cells and disturbs the impulse propagation that causes the heart to beat regularly.[ref] Animal studies from about a decade ago show a pressure overload in the heart (stressing out the heart) can cause mast cells to proliferate