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It has been evaluated in multiple Phase 3 randomized controlled trials, meta-analyses, and a Cochrane systematic review across indications including Alzheimer's disease, vascular dementia, and stroke

Approximately 900 adult participants were enrolled across six randomized, double-blind, placebo-controlled clinical trials conducted between 2001 and 2006

Biological functions and subcellular localization data were sourced from the UniProt Knowledgebase ( 36

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Severe events that have been reported and contributed to discontinuation include IgE-mediated hypersensitivity in 4% of participants in some trials, with one reported anaphylaxis-like reaction [wong (2008) abstract]

Measuring acute postoperative pain using the visual analog scale: the minimal clinically important difference and patient acceptable symptom state