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If tirzepatide has stopped working or weight loss has stalled despite dose escalation, adding AOD 9604 introduces a new mechanism that can restart progress

Heidi Spratt for advice regarding the statistical analyses

Worsening macrocytic anemia : B 12 deficiency may also cause a macrocytic (megaloblastic) anemia BUT, in the presence of folate supplementation, this anemia may be masked so that B 12 deficiency may present with exclusively neurologic features

Diet: Vegans and vegetarians often lack animal products, which are key for B12

Also known as cobalamin, Vitamin B12 helps your body produce DNA, supports brain and nervous system health, and aids in maintaining healthy red blood cells

If a significant deficiency is left untreated over time, some of this nerve damage can become permanent, which is why prompt evaluation matters